You might be surprised to learn that the sexually transmitted human papilloma virus (hpv) is a leading cause of throat cancers, and it. Oral sex does not directly cause throat cancer, but it can spread hpv. Hpv can cause pre-cancerous changes in cells that may lead to throat cancer later on. the human papillomavirus (hpv) has been linked to an increase in throat cancer diagnoses from oral sex. But we do know that hpv-related oropharyngeal cancer (the part of the throat directly behind the mouth) is twice as common in men than women, and is most common in heterosexual men in their 40s and 50s. This may indicate that giving oral sex to a woman is more risky than giving oral sex to a man. Women with 10 or more lifetime oral sex partners had a relatively low, 3. 0 percent prevalence of infection, whereas for men with 10 or more lifetime oral sex partners, the figure was 14. Its still unclear how many people get hpv throat infections by oral sex, or how many of them get oropharyngeal cancer, brawley reports. increasing rates of hpv infection, spread through oral sex, is largely driving the rapid rise in oropharyngeal cancers, which include tumors of the throat, tonsils, and base of the tongue, said. Rates of hpv-related throat cancer are on the rise in men, especially those who smoke or have had five or more oral-sex partners, according to a 2017 study in the annals of oncology.