You might be surprised to learn that the sexually transmitted human papilloma virus (hpv) is a leading cause of throat cancers, and it. The number of oral sex-related throat cancers are risingheres why. Theres very little research thats looked at the possible risks from giving oral sex to a man compared with giving oral sex to a woman. But we do know that hpv-related oropharyngeal cancer (the part of the throat directly behind the mouth) is twice as common in men than women, and is most common in heterosexual men in their 40s and 50s. increasing rates of hpv infection, spread through oral sex, is largely driving the rapid rise in oropharyngeal cancers, which include tumors of the throat, tonsils, and base of the tongue, said. Oral sex does not directly cause throat cancer, but it can spread hpv. Hpv can cause pre-cancerous changes in cells that may lead to throat cancer later on. Actor michael douglas, 75, infamously blamed his throat cancer diagnosis on his fondness for oral sex. (although the actor and husband of catherine zeta-jones, 50, later backpedaled on that claim.).