1 risk in contracting oral hpv and developing hpv-related throat cancer is having multiple oral sex partners, dr. increasing rates of hpv infection, spread through oral sex, is largely driving the rapid rise in oropharyngeal cancers, which include tumors of the throat, tonsils, and base of the tongue, said. oral sex increases risk of throat cancer date may 10, 2007 source johns hopkins medical institutions summary researchers at the johns hopkins kimmel cancer center have conclusive evidence that. the human papillomavirus (hpv) has been linked to an increase in throat cancer diagnoses from oral sex. Oral sex does not directly cause throat cancer, but it can spread hpv. Hpv can cause pre-cancerous changes in cells that may lead to throat cancer later on.